Panama Canal Cruises
Compare 14 Panama Canal cruises in our guide, sailing with 7 cruise lines on itineraries from 7 Nights to 22 Nights. Every cruise includes the full port-by-port itinerary, an interactive route map, and traveler insights sourced from real reviews.
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Panama Canal
11 Nights · 6 Ports
Celebrity Ascent - Panama Canal & Southern Caribbean
4.6(160 reviews)
Departs Fort Lauderdale, FL
CartagenaPanama Canal (Gatun Lake)ColonOranjestad+2 more
Bucket List TravelersCouples
$
Panama Canal
12 Nights · 6 Ports
Rotterdam - Panama Canal Sunfarer from Fort Lauderdale
4.4(336 reviews)
Departs Fort Lauderdale, FL
Half Moon CayWillemstadCartagenaPanama Canal (Gatun Lake)+2 more
Classic CruisersRetirees
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Panama Canal
22 Nights · 12 Ports
Norwegian Encore - Panama Canal Repositioning
4.3(831 reviews)
Departs Miami, Florida
CartagenaPanama Canal (Scenic Cruising)Panama City (Fuerte Amador)Puntarenas+8 more
SeniorsAdventure Seekers
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Panama Canal
16 Nights · 8 Ports
Norwegian Bliss - Panama Canal from Los Angeles to Miami
4.2(1,555 reviews)
Departs Los Angeles, California
Cabo San LucasAcapulcoPuerto QuetzalPuerto Caldera+4 more
SeniorsHistory Buffs
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Panama Canal
21 Nights · 11 Ports
Norwegian Joy - Panama Canal Repositioning: Seattle to Miami
4.2(1,124 reviews)
Departs Seattle, WA
VictoriaSan Francisco, CASan Francisco, CALos Angeles, CA+7 more
Bucket List TravelersScenic Cruisers
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Panama Canal
12 Nights · 6 Ports
Nieuw Amsterdam - Panama Canal Discovery: Costa Rica & Greater Antilles
4.2(839 reviews)
Departs Fort Lauderdale, Florida
Half Moon CayOranjestadCartagenaPanama Canal (Gatun Lake) & Cristobal+2 more
SeniorsCouples
$$$
Panama Canal
20 Nights · 15 Ports
Marina - Panama Canal Navigator: Double Transit from Miami
4.2(242 reviews)
Departs Miami, FL
CozumelCosta MayaHarvest CayeSanto Tomas de Castilla+11 more
FoodiesLuxury Travelers
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Panama Canal
21 Nights · 11 Ports
Eurodam - Panama Canal Repositioning: Seattle to Fort Lauderdale
4.1(1,170 reviews)
Departs Seattle, WA
VancouverSanta Barbara, CASan Diego, CACabo San Lucas+7 more
Bucket List TravelersScenic Cruisers
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Panama Canal
16 Nights · 7 Ports
Emerald Princess - Panama Canal Ocean to Ocean
4(1,249 reviews)
Departs Los Angeles, California
Puerto VallartaHuatulcoPuerto QuetzalPuntarenas+3 more
SeniorsHistory Buffs
$$
Panama Canal
14 Nights · 5 Ports
Zuiderdam - Panama Canal Passage
4(811 reviews)
Departs Fort Lauderdale, FL
Half Moon CayAruba (Oranjestad)CartagenaPanama Canal (Transit)+1 more
Bucket List SeekersHistory Buffs
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Panama Canal
20 Nights · 7 Ports
Queen Elizabeth - Panama Canal Crossing: Miami to Seattle
4(159 reviews)
Departs Miami, FL
CartagenaColonPanama Canal (Transit)Puntarenas+3 more
Classic CruisersBucket List Travelers
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Panama Canal
12 Nights · 5 Ports
Caribbean Princess - Panama Canal from Fort Lauderdale
3.9(2,001 reviews)
Departs Fort Lauderdale, FL
Willemstad, CuracaoCartagenaPanama Canal (Gatun Lake) & ColonPuerto Limon+1 more
SeniorsHistory Buffs
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Panama Canal
11 Nights · 8 Ports
Norwegian Jade - Panama Canal Repositioning: Tampa to Panama City
3.9(1,528 reviews)
Departs Tampa, FL
Key West, FLCozumelGeorge TownOcho Rios+4 more
Value SeekersBucket List Travelers
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