South America Cruises

Compare 10 South America cruises in our guide, sailing with 9 cruise lines on itineraries from 4 Nights to 18 Nights. Every cruise includes the full port-by-port itinerary, an interactive route map, and traveler insights sourced from real reviews.

Majestic Princess cruise ship
$$
South America
17 Nights · 8 Ports
Princess Cruises·Majestic Princess

Majestic Princess - Antarctica & South America from Buenos Aires

4.4(536 reviews)

Departs Buenos Aires, Argentina

StanleyElephant Island (Scenic Cruising)Antarctic SoundGerlache Strait (Scenic Cruising)+4 more
Bucket List SeekersWildlife Enthusiasts
Carnival Firenze cruise ship
$
South America
14 Nights · 8 Ports
Carnival Cruise Line·Carnival Firenze

Carnival Firenze - Chilean Fjords & Cape Horn: Santiago to Buenos Aires

4.2(280 reviews)

Departs San Antonio (Santiago), Chile

Darwin Channel (Scenic Cruising)Chilean Fjords (Scenic Cruising)Amalia Glacier (Scenic Cruising)Strait of Magellan (Scenic Cruising)+4 more
Bucket List TravelersScenic Cruisers
Marina cruise ship
$$$
South America
18 Nights · 13 Ports
Oceania Cruises·Marina

Marina - Cape Horn Encounter: Santiago to Buenos Aires

4.2(242 reviews)

Departs San Antonio (Santiago), Chile

Puerto MonttPuerto ChacabucoLaguna San Rafael (Scenic Cruising)Chilean Fjords (Scenic Cruising)+9 more
Scenic CruisersRetirees
Seven Seas Mariner cruise ship
$$$$$
South America
11 Nights · 8 Ports
Regent Seven Seas·Seven Seas Mariner

Seven Seas Mariner - Nights of Samba & Tango: Rio to Buenos Aires

4(103 reviews)

Departs Rio de Janeiro, Brazil

BuziosIlha GrandeIlhabelaSao Francisco do Sul+4 more
Luxury TravelersCulture Seekers
Seven Seas Mariner cruise ship
$$$$$
South America
18 Nights · 10 Ports
Regent Seven Seas·Seven Seas Mariner

Seven Seas Mariner - Colossal Coastlines: Antarctica & the Falklands

4(103 reviews)

Departs Buenos Aires, Argentina

Puerto MadrynPunta ArenasPunta ArenasUshuaia+6 more
Bucket List TravelersLuxury Travelers
MSC Divina cruise ship
$
South America
4 Nights · 2 Ports
MSC Cruises·MSC Divina

MSC Divina - Brazilian Getaway: Buzios & Ilha Grande

3.8(1,611 reviews)

Departs Santos (Sao Paulo), Brazil

BuziosIlha Grande
Budget TravelersBeach Lovers
Explora I cruise ship
$$$$$
South America
12 Nights · 8 Ports
Explora Journeys·Explora I

Explora I - Caribbean to the Amazon

Departs San Juan, Puerto Rico

GustaviaSaint-PierreBridgetownPort of Spain+4 more
Luxury TravelersAdventure Seekers
MS Roald Amundsen cruise ship
$$$$
South America
13 Nights · 10 Ports
Hurtigruten·MS Roald Amundsen

MS Roald Amundsen - Chilean Fjords & Patagonia

Departs Ushuaia, Argentina

Garibaldi FjordAinsworth BayStrait of Magellan (Scenic Cruising)White Narrows (Scenic Cruising)+6 more
Adventure SeekersNature Lovers
Silver Nova cruise ship
$$$$$
South America
9 Nights · 6 Ports
Silversea·Silver Nova

Silver Nova - Rio de Janeiro to Buenos Aires

Departs Rio de Janeiro, Brazil

Rio de JaneiroIlhabelaPorto BeloPunta del Este+2 more
Luxury TravelersCouples
Seabourn Pursuit cruise ship
$$$$$
South America
10 Nights · 7 Ports
Adults Only
Seabourn·Seabourn Pursuit

Seabourn Pursuit - Chilean Fjords Expedition: Santiago to Ushuaia

Departs San Antonio (Santiago), Chile

Puerto MonttMoraleda & Darwin Channels (Scenic Cruising)Caleta TortelPio XI Glacier (Eyre Fjord)+3 more
Adventure SeekersLuxury Seekers

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