South America Cruises

Compare 10 South America cruises in our guide, sailing with 9 cruise lines on itineraries from 4 Nights to 18 Nights. Every cruise includes the full port-by-port itinerary, an interactive route map, and traveler insights sourced from real reviews.

South American cruising happens in the southern summer and splits into a few distinct trips. The signature one sails around the bottom of the continent between Buenos Aires and San Antonio, the port for Santiago (some versions return to Buenos Aires instead): Montevideo, Puerto Madryn, the Falklands, Cape Horn, Ushuaia, Punta Arenas and the Chilean fjords, over two weeks or more. Brazil's coast is the second, with Santos (for Sao Paulo) and Rio de Janeiro as home ports. The Amazon is the third - long voyages that sail upriver from the Atlantic - and a few expedition trips combine the Falklands with the Antarctic Peninsula.

Expect weather to edit a southern itinerary. Stanley in the Falklands is a tender port for big ships, and wind and swell commonly stop the tenders, so treat a Falklands penguin tour as a hope rather than a plan. The fjords and Cape Horn are scenic cruising, also at the mercy of conditions. Pack for everything from Buenos Aires heat to near-freezing wind on deck in the same fortnight.

The document trap is Brazil. Since April 10, 2025, U.S., Canadian and Australian citizens need a visa for Brazil, whatever the reason for the visit, and that includes arriving by cruise ship even for a single port day. The e-visa costs $80.90 through Brazil's official portal and usually takes a few days. On March 30, 2026, nearly 100 passengers were refused boarding on a Celebrity sailing from Buenos Aires for not having one, with no compensation, so apply weeks ahead if any Brazilian port is on the route.

Many are one-way trips that need flights in and out of different cities, which makes them better suited to travelers with time and a taste for landscapes and wildlife than to anyone wanting a quick beach week.

Sources: tripprof.com, cruisedealstipsandtricks.com, cruiseweb.com

Port guides for South America

South America itineraries

Majestic Princess cruise ship
$$
South America
17 Nights · 8 Ports
Princess Cruises·Majestic Princess

Majestic Princess - Antarctica & South America from Buenos Aires

4.4(536 reviews)

Departs Buenos Aires

StanleyElephant IslandAntarctic SoundGerlache Strait (Scenic Cruising)+4 more
Bucket List SeekersWildlife Enthusiasts
Explora I cruise ship
$$$$$
South America
12 Nights · 8 Ports
Explora Journeys·Explora I

Explora I - Caribbean to the Amazon

4.4(24 reviews)

Departs San Juan

GustaviaSaint-PierreBridgetownPort of Spain+4 more
Luxury TravelersAdventure Seekers
Silver Nova cruise ship
$$$$$
South America
9 Nights · 6 Ports
Silversea·Silver Nova

Silver Nova - Rio de Janeiro to Buenos Aires

4.3(11 reviews)

Departs Rio de Janeiro

Rio de JaneiroIlhabelaPorto BeloPunta del Este+2 more
Luxury TravelersCouples
Carnival Firenze cruise ship
$
South America
14 Nights · 8 Ports
Carnival Cruise Line·Carnival Firenze

Carnival Firenze - Chilean Fjords & Cape Horn: Santiago to Buenos Aires

4.2(280 reviews)

Departs San Antonio (Santiago)

Darwin Channel (Scenic Cruising)Chilean Fjords (Scenic Cruising)Amalia Glacier (Scenic Cruising)Strait of Magellan (Scenic Cruising)+4 more
Bucket List TravelersScenic Cruisers
Marina cruise ship
$$$
South America
18 Nights · 13 Ports
Adults Only
Oceania Cruises·Marina

Marina - Cape Horn Encounter: Santiago to Buenos Aires

4.2(242 reviews)

Departs San Antonio (Santiago)

Puerto MonttPuerto ChacabucoLaguna San Rafael (Scenic Cruising)Chilean Fjords (Scenic Cruising)+9 more
Scenic CruisersRetirees
Seven Seas Mariner cruise ship
$$$$$
South America
11 Nights · 8 Ports
Regent Seven Seas·Seven Seas Mariner

Seven Seas Mariner - Nights of Samba & Tango: Rio to Buenos Aires

4(103 reviews)

Departs Rio de Janeiro

BuziosIlha GrandeIlhabelaSao Francisco do Sul+4 more
Luxury TravelersCulture Seekers
Seven Seas Mariner cruise ship
$$$$$
South America
18 Nights · 10 Ports
Regent Seven Seas·Seven Seas Mariner

Seven Seas Mariner - Colossal Coastlines: Antarctica & the Falklands

4(103 reviews)

Departs Buenos Aires

Puerto MadrynPunta ArenasPunta ArenasUshuaia+6 more
Bucket List TravelersLuxury Travelers
MSC Divina cruise ship
$
South America
4 Nights · 2 Ports
MSC Cruises·MSC Divina

MSC Divina - Brazilian Getaway: Buzios & Ilha Grande

3.8(1,611 reviews)

Departs Santos (Sao Paulo)

BuziosIlha Grande
Budget TravelersBeach Lovers
MS Roald Amundsen cruise ship
$$$$
South America
13 Nights · 10 Ports
Hurtigruten·MS Roald Amundsen

MS Roald Amundsen - Chilean Fjords & Patagonia

Departs Ushuaia

Garibaldi FjordAinsworth BayStrait of Magellan (Scenic Cruising)White Narrows (Scenic Cruising)+6 more
Adventure SeekersNature Lovers
Seabourn Pursuit cruise ship
$$$$$
South America
10 Nights · 7 Ports
Adults Only

Seabourn Pursuit - Chilean Fjords Expedition: Santiago to Ushuaia

Departs San Antonio (Santiago)

Puerto MonttMoraleda & Darwin Channels (Scenic Cruising)Caleta TortelPio XI Glacier (Eyre Fjord)+3 more
Adventure SeekersLuxury Seekers